One of the most “pimped” questions in all of medicine is, “What causes osteomyelitis in sickle cell patients?”
Some say Salmonella, but this is not entirely true. The most common cause of osteomyelitis is still Staphylococcus aureus. However, if you have a patient with osteomyelitis caused by Salmonella, he or she is most likely to also have sickle cell disease. See the difference? Why do they get Salmonella? It is because Salmonella loves hemosiderin, the breakdown product of red blood cells. Sickle cell patients have a large hemosiderin deposit in their bones, which Salmonella loves. Overall, Salmonella is not the most common cause of osteomyelitis, but if you see it, think sickle cell. Now, you can pimp the pimper back!